Recent Publications

Montaser H, Leppanen S, Vahakangas E, Back N, Grace A, Eurola S, Ibrahim H, Lithovius V, Stephens SB, Barsby T, Balboa D, Saarimaki-Vire J, Otonkoski T. IER3IP1 mutations cause neonatal diabetes due to impaired proinsulin trafficking. Diabetes 2024 Oct 23:db240119. doi: 10.2337/db24-0119. PMID: 39441964

Stephens, SB. Deciphering cytokine responsive and non-responsive human β-cells. Function. 2024 Sep 9:zqae039. doi: 10.1093/function/zqae039. PMID: 39251388

Rohli KE, Stubbe NJ, Walker EM, Pearson GL, Soleimanpour SA, Stephens SB. A metabolic redox relay supports ER proinsulin export in pancreatic islet β-cells. JCI Insight. 2024 Jun 27:e178725. doi: 10.1172/jci.insight.178725. PMID: 38935435

Woo M, Bal L, Winschel I, Manca E, Walkenhorst M, Sevgili B, Sonner JK, Liberto G, Mayer C, Binkle-Ladisch L, Rothammer N, Unger L, Raich L, Vieira V, Meurs N, Wagner I, Cocco C, Stephens SB, Glatzel M, Merkler D, Friese M. Neuroinflammation-induced NR4A2-VGF pathway activation fuels neurodegeneration through increased neuronal glycolysis. JCI Insight. 2024 Jun 18;134(16):e177692. doi: 10.1172/JCI177692. PMID: 39145444

Boyer CK, Blom, SE, Machado AE, Rohli KE, Maxson ME, Stephens SB. Loss of the Golgi-localized v-ATPase subunit does not alter insulin granule formation or pancreatic islet beta-cell function. American Journal of Physiology-Endocrinology and Metabolism. 2024 Jan 24. PMID 38265287

Sue N, Thai LM, Saito A, Boyer CK, Fordham AM, Yan C, Davenport A, Tao J, Bensellam M, Cantley J, Shi YC, Stephens SB , Imaizumi K, Biden TJ. Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by coordinating insulin biosynthesis with secretory granule formation. Molecular Metabolism. 2023 Nov 25:101845. PMID 38013154

Brennecke BR, Yang U, Liu S, Ilerisoy FS, Ilerisoy BN, Joglekar A, Kim LB, Peachee SJ, Richtmeier SL, Stephens SB, Sander EA, Strack S, Moninger TO, Ankrum JA, and Imai Y. The utilization of commercial collagens for preparing well-differentiated human beta cells for confocal microscopy. Frontiers in Endocrinology. 2023. PMID: 37305047

Boyer CK, Bauchle CJ, Zhang J, Wang Y, Stephens SB . Synchronized proinsulin trafficking reveals delayed Golgi export accompanies β-cell secretory dysfunction in rodent models of hyperglycemia. Scientific Reports. 2023; 13(1):5218. PMID 36997560

Rohli KE, Boyer CK, Bearrows SC, Moyer MR, Elison WS, Bauchle CJ, Blom SE, Zhang J, Wang Y, Stephens SB. ER redox homeostasis regulates proinsulin trafficking and insulin granule formation in the pancreatic islet β-cell. Function. Volume 3, Issue 6, 2022. PMID 36325514

Parchure A, Tian M, Boyer CK, Bearrows SC, Rohli KE, Zhang J, Ramazanov BR, Wang Y, Stephens SB, von Blume J. Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules. J Cell Biol. 2022 Dec 5;221(12):e202206132. PMID: 36173346

Rohli KE, Boyer CK, Blom SE, Stephens SB. Nutrient Regulation of Pancreatic Islet β-Cell Secretory Capacity and Insulin Production. Biomolecules. 2022 Feb 20;12(2):335. doi: 10.3390/biom12020335. PMID: 35204835

Li M, Shao F, Qian Q, Yu W, Zhang Z, Chen B, Su D, Guo Y, Phan A, Song L, Stephens SB, Sebag JA, Imai Y, Yang L, Cao H. A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β-cells. Molecular Therapy Nucleic Acids. 2021 Jul 16;26:307-32.PMID: 34513312

Maharjan CK, Umesalma S, Kaemmer CA, Muniz VP, Bauchle C, Mott SL, Zamba KD, Breheny P, Leidinger MR, Darbro BW, Stephens SB, Meyerholz DK, Quelle DE. RABL6A Promotes Pancreatic Neuroendocrine Tumor Angiogenesis and Progression In Vivo. Biomedicines. 2021 Jun 2; vol 9(6) doi: 10.3390/biomedicines9060633. PMID: 34199469

Bauchle CJ, Rohli KE, Boyer CK, Pal V, Rocheleau JV, Liu S, Imai Y, Taylor EB, Stephens SB. Mitochondrial efflux of citrate and isocitrate is fully dispensable for glucose-stimulated insulin secretion and pancreatic islet β-cell function. Diabetes. 2021 May; db210037. PMID: 34039628 
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Mishra A, Liu S, Promes J, Harata M, Sivitz WI, Fink BD, Bhardwaj G, O'Neill BT, Kang C, Sah R, Strack S, Stephens SB, King TH, Jackson L, Greenberg AS, Anokye-Danso F, Ahima RS, Ankrum JA, Imai Y. Perilipin2 down-regulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria. JCI Insight. 2021 Mar 30:144341. doi: 10.1172/jci.insight.144341. PMID: 33784258

Huynh F, Peterson B, Anderson K, Lin Z, Coakley A, Llaguno F, Nguyen T, Campbell J, Stephens S, Newgard C, Hirschey M. Beta-cell specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice. American J Physiology Endocrinology and Metabolism. 2020. 319(4): E805-813. PMID: 32865009

Yin T, Bauchle CJ, Stephens SB, Sebag JA. The insulinostatic effect of ghrelin requires MRAP2 expression in δ-cell. iScience. 2020. 23(6):101216.PMID: 32535024

Liu S, Promes JA, Harata M, Mishra A, Stephens SB, Taylor EB, Burand A, Sivitz W, Fink B, Ankrum JA, Imai Y. Adipose triglyceride lipase is a key lipase for the mobilization of lipid droplets in human beta cells and critical for the maintenance of syntaxin1a level in β-cells. Diabetes 2020

Hohmeier HE, Zhang L, Taylor, B, Stephens SB, McNamara P, Laffitte B, Newgard CB. Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells. PLoS One. 2020 15(3):e0224344

Bearrows SC, Bauchle CJ, Becker M, Haldeman JM, Swaminathan S, Stephens SB. Chromogranin B regulates early stage insulin granule trafficking from the Golgi in pancreatic islet β-cells. J Cell Sci. 2019 132(13)
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Kang C, Xie L, Gunasekar SK, Mishra A, Zhang Y, Pai S, Gao Y, Kumar A, Norris AW, Stephens SB, Sah R. SWELL1 is a glucose sensor regulating ß-cell excitability and systemic glycaemia. Nat Comm. 2018 25(9):367

Hayes HL, Peterson BS, Haldeman JM, Newgard CB, Hohmeier HE, Stephens SB. Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival. PLoS One. 2017; 12(2): e0172567.

Stephens SB, Edward RJ, Sadahiro M, Lin W, Jiang C, Salton SR, and Newgard CB. The Prohormone VGF Regulates β-cell Function via Insulin Secretory Granule Biogenesis. 2017 Sep 5;20(10):2480-2489 PMID: 28877479

Hayes HL, Zhang L, Becker TC, Haldeman JM, Stephens SB, Arlotto M, Moss LG, Newgard, CB, Hohmeier HE.A Pdx-1 regulated soluble factor activates rat and human islet cell proliferation. Mol Cell Biol. 2016; 35(23): 2918-30.

Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB. Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(14):5242-7.

Stephens SB, Schisler JC, Hohmeier HE, An J, Sun AY, et al. A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. Cell Metabolism. 2012; 16(1):33-43.