Recent Publications

Maharjan CK, Umesalma S, Kaemmer CA, Muniz VP, Bauchle C, Mott SL, Zamba KD, Breheny P, Leidinger MR, Darbro BW, Stephens SB, Meyerholz DK, Quelle DE. RABL6A Promotes Pancreatic Neuroendocrine Tumor Angiogenesis and Progression In Vivo. Biomedicines. 2021 Jun 2; vol 9(6) doi: 10.3390/biomedicines9060633. PMID: 34199469

Bauchle CJ, Rohli KE, Boyer CK, Pal V, Rocheleau JV, Liu S, Imai Y, Taylor EB, Stephens SB. Mitochondrial efflux of citrate and isocitrate is fully dispensable for glucose-stimulated insulin secretion and pancreatic islet β-cell function. Diabetes. 2021 May; db210037
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Mishra A, Liu S, Promes J, Harata M, Sivitz WI, Fink BD, Bhardwaj G, O'Neill BT, Kang C, Sah R, Strack S, Stephens SB, King TH, Jackson L, Greenberg AS, Anokye-Danso F, Ahima RS, Ankrum JA, Imai Y. Perilipin2 down-regulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria. JCI Insight. 2021 Mar 30:144341. doi: 10.1172/jci.insight.144341. Epub ahead of print. PMID: 33784258.

Huynh F, Peterson B, Anderson K, Lin Z, Coakley A, Llaguno F, Nguyen T, Campbell J, Stephens S, Newgard C, Hirschey M. Beta-cell specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice. American J Physiology Endocrinology and Metabolism. 2020. 319(4): E805-813

Yin T, Bauchle CJ, Stephens SB, Sebag JA. The insulinostatic effect of ghrelin requires MRAP2 expression in δ-cell. iScience. 2020. 23(6):101216

Liu S, Promes JA, Harata M, Mishra A, Stephens SB, Taylor EB, Burand A, Sivitz W, Fink B, Ankrum JA, Imai Y. Adipose triglyceride lipase is a key lipase for the mobilization of lipid droplets in human beta cells and critical for the maintenance of syntaxin1a level in β-cells. Diabetes 2020

Hohmeier HE, Zhang L, Taylor, B, Stephens SB, McNamara P, Laffitte B, Newgard CB. Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells. PLoS One. 2020 15(3):e0224344

Bearrows SC, Bauchle CJ, Becker M, Haldeman JM, Swaminathan S, Stephens SB. Chromogranin B regulates early stage insulin granule trafficking from the Golgi in pancreatic islet β-cells. J Cell Sci. 2019 132(13)
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Kang C, Xie L, Gunasekar SK, Mishra A, Zhang Y, Pai S, Gao Y, Kumar A, Norris AW, Stephens SB, Sah R. SWELL1 is a glucose sensor regulating ß-cell excitability and systemic glycaemia. Nat Comm. 2018 25(9):367

Hayes HL, Peterson BS, Haldeman JM, Newgard CB, Hohmeier HE, Stephens SB. Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival. PLoS One. 2017; 12(2): e0172567.

Hayes HL, Zhang L, Becker TC, Haldeman JM, Stephens SB, Arlotto M, Moss LG, Newgard, CB, Hohmeier HE.  A Pdx-1 regulated soluble factor activates rat and human islet cell proliferation. Mol Cell Biol. 2016; 35(23): 2918-30.

Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB. Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(14):5242-7.

Stephens SB, Schisler JC, Hohmeier HE, An J, Sun AY, et al. A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. Cell Metabolism. 2012; 16(1):33-43.